Increased Levels of Neurotrophins Are Not Specific for Chronic Migraine: Evidence from Primary Fibromyalgia Syndrome.

Sarchielli P, Mancini ML, Floridi A, Coppola F, Rossi C, Nardi K, Acciarresi M, Alberto Pini L, Calabresi P.

Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy.

All data obtained in experimental animal pain models support the role of nerve growth factor (NGF) as a putative candidate intervening in the pathogenesis of chronic pain, including chronic daily headache (CDH). Few studies have been carried out to establish its role in maintaining pain states in humans. The present study was aimed at investigating cerebrospinal fluid (CSF) levels of NGF and brain-derived neurotrophic factor (BDNF), both measured by sensitive immunoassay, in 20 chronic migraine (CM) patients and 20 patients affected by primary fibromyalgia syndrome (PFMS), compared with those of 20 age-matched control subjects. Significantly higher levels of both neurotrophins and glutamate were found. A significantly positive correlation emerged between CSF values of BDNF and those of NGF (See Note) in CM and PFMS patients, respectively. These findings suggest the possibility of a NGF-mediated up-regulation of BDNF involved in the pathophysiological events underlying long-term neuroplastic changes in persistent chronic painful conditions, such as CM and fibromyalgia. NGF might indirectly exert its effect through enhancing glutamatergic transmission via BDNF. The above mechanisms could account for sustained central sensitization in both chronic pain states. PERSPECTIVE: This article presents findings of higher NGF and BDNF levels correlated to increased glutamate levels in the CSF of both chronic migraine and fibromyalgia patients. This opens new insights into the pathogenic mechanisms of chronic pain and offers clinicians new therapeutic perspectives targeting the above mechanisms in both painful disorders.

PMID: 17611164 [PubMed – as supplied by publisher]

1: J Pain. 2007 Jul 3; [Epub ahead of print]

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Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
This entry was posted in Britain, British, Chronic Fatigue, Chronic Fatigue Syndrome, Chronic Multisymptom Illness, Chronic Pain, Chronic Pain Disorders, Chronic Widespread Pain, Clinical, Clinical Pain, Diseases, Dysfunctional Pain Processing, Dysfunctional Pain Syndrome, Europe, Fatigue, Feeds, Fibrohugs, Fibrohugs News, Fibromyalgia, Fibromyalgia Blogs, Fibromyalgia News, Fibromyalgia News Belgium, Fibromyalgia News Denmark, Fibromyalgia News Deutschland, Fibromyalgia News France, Fibromyalgia News Israel, Fibromyalgia News Italy, Fibromyalgia News Japan, Fibromyalgia News Jerusalem, Fibromyalgia News Korea, Fibromyalgia News Southeast Asia, Fibromyalgia News Turkey, Fibromyalgia News Wisconsin, Fibromyalia News Germany, FMS, FMS Global News, FSS, Functional Somatic Syndrome, Global News, Health, Hypersensitivity, Invisible Illness, Invisible Illnesses, Italy, Japan, Medical, Medical Journals, Medical Research, Medical University, Mexico, Mexico City, Montreal, Myofacial Pain Syndrome, News, News Australia, News Belgium, News Canada, News Denmark, News France, News India, News Ireland, News Israel, News Italy, News Japan, News Jerusalem, News Korea, News Montreal, News Nigeria, News Norway, News Quebec, News Saskatchewan, News Scotland, News Southeast Asia, News Spain, News Sweden, News Toronto, News Turkey, News UK, News Wisconsin, Nigeria, Non Malignant Chronic Pain, North Carolina, Ontario, Ottawa, Ottawa City Feed, Oxford, Pain, Pain Management, PFMS, Philadelphia, Portugal, Primary Fibromyalgia Syndrome, Research, RSS, Seattle, Somatic Pain, Southeast Asia, Spain, Stockholm, Surrey and Sussex, Swedish, Switzerland, Syndromes, Tenderpoints, The Netherlands., Toronto, Toronto City Feed, Universities, US, USA, Virginia, Washington D.C. City Feed, Washington DC, World, World News. Bookmark the permalink.

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