Fibromyalgia patients show an abnormal dopamine response to pain.

Wood PB, Schweinhardt P, Jaeger E, Dagher A, Hakyemez H, Rabiner EA, Bushnell MC, Chizh BA.

McGill University Centre for Research on Pain, Faculty of Dentistry, 3640 University Street, Strathcona Building, Montreal, QC, Canada, H3A 2B2.

Fibromyalgia is characterized by chronic widespread pain and bodily tenderness and is often accompanied by affective disturbances. Accumulating evidence indicates that fibromyalgia may involve a dysfunction of modulatory systems in the brain. While brain dopamine is best known for its role in pleasure, motivation and motor control, recent evidence suggests that it is also involved in pain modulation. Because dopamine is implicated in both pain modulation and affective processing, we hypothesized that fibromyalgia may involve a disturbance of dopaminergic neurotransmission. Fibromyalgia patients and matched healthy control subjects were subjected to deep muscle pain produced by injection of hypertonic saline into the anterior tibialis muscle. In order to determine the endogenous release of dopamine in response to painful stimulation, we used positron emission tomography to examine binding of [(11)C]-raclopride (D2/D3 ligand) in the brain during injection of painful hypertonic saline and nonpainful normal saline. Fibromyalgia patients experienced the hypertonic saline as more painful than healthy control subjects. Control subjects released dopamine in the basal ganglia during the painful stimulation, whereas fibromyalgia patients did not. In control subjects, the amount of dopamine release correlated with the amount of perceived pain but in fibromyalgia patients no such correlation was observed. These findings provide the first direct evidence that fibromyalgia patients have an abnormal dopamine response to pain. The disrupted dopaminergic reactivity in fibromyalgia patients could be a critical factor underlying the widespread pain and discomfort in fibromyalgia and suggests that the therapeutic effects of dopaminergic treatments for this intractable disorder should be explored.

PMID: 17610577 [PubMed – in process]

1: Eur J Neurosci. 2007 Jun;25(12):3576-82.

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Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
This entry was posted in Britain, British, Chronic Pain, Chronic Pain Disorders, Chronic Widespread Pain, Clinical Pain, Dysfunctional Pain Processing, Dysfunctional Pain Syndrome, Europe, Fatigue, Feeds, Fibrohugs, Fibrohugs News, Fibromyalgia, Fibromyalgia Blogs, Fibromyalgia News, Fibromyalgia News Belgium, Fibromyalgia News Denmark, Fibromyalgia News Deutschland, Fibromyalgia News France, Fibromyalgia News Israel, Fibromyalgia News Italy, Fibromyalgia News Japan, Fibromyalgia News Jerusalem, Fibromyalgia News Korea, Fibromyalgia News Southeast Asia, Fibromyalgia News Turkey, Fibromyalgia News Wisconsin, Fibromyalgia Press Releases, Fibromyalia News Germany, Finland, FMS, FMS Global News, FSS, Functional Somatic Syndrome, Global News, Health, Hypersensitivity, Invisible Illness, Invisible Illnesses, Italy, Japan, Medical, Medical Journals, Medical Research, Medical University, Mexico, Mexico City, Montreal, News, News Australia, News Belgium, News Canada, News Denmark, News France, News India, News Ireland, News Israel, News Italy, News Japan, News Jerusalem, News Korea, News Montreal, News Nigeria, News Norway, News Quebec, News Saskatchewan, News Scotland, News Southeast Asia, News Spain, News Sweden, News Toronto, News Turkey, News UK, News Wisconsin, Nigeria, North Carolina, Ontario, Ottawa, Ottawa City Feeds, Pain, Pain Management, Philadelphia, Quality of Life, Quebec, Research, RLS, RSS, Seattle, Sleep Disorders, Sleep Disturbance, Sleep Quality, Somatic Pain, Southeast Asia, Spain, Stockholm, Surrey and Sussex, Swedish, Switzerland, Tenderpoints, The Netherlands., Toronto, Universities, US, USA, Virginia, World, World News, World Wide, Worldwide. Bookmark the permalink.

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