Genetics of chronic pain states.

Buskila D.

Department of Medicine H, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University, Beer Sheva, P.O.B 151, Israel 84101.

Chronic pain states are common in the general population. Genetic factors can explain a significant amount of the variability in the perception of pain. Fibromyalgia syndrome (FMS) and related conditions are syndromes characterized by generalized pain sensitivity as well as a constellation of other symptoms. Family studies show a strong familial aggregation of FMS and related conditions, suggesting the importance of genetic factors in the development of these conditions. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the pathogenesis of FMS and related conditions. Environmental factors may trigger the development of these disorders in genetically predisposed individuals. Future large well-designed studies are needed to further clarify the role of genetic factors in FMS and related conditions. The knowledge of these gene polymorphisms may help with better subgrouping of FMS patients and in designing a more specific pharmacologic treatment approach.

PMID: 17602998 [PubMed – in process]

1: Best Pract Res Clin Rheumatol. 2007 Jun;21(3):535-47.

Genetics of chronic pain states.
Best Practice & Research Clinical Rheumatology, Volume 21, Issue 3, Pages 535-547
D. Buskila

Reference

FMS Global News

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About FMS Global News

Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
This entry was posted in Article, Britain, British, CFS, Chronic Fatigue, Chronic Pain, Chronic Pain Disorders, Chronic Widespread Pain, Clinical Pain, Dysfunctional Pain Syndrome, Europe, Fatigue, Feeds, Fibrohugs, Fibrohugs News, Fibromyalgia, Fibromyalgia Blogs, Fibromyalgia News, Fibromyalgia News Belgium, Fibromyalgia News Denmark, Fibromyalgia News Deutschland, Fibromyalgia News France, Fibromyalgia News Israel, Fibromyalgia News Italy, Fibromyalgia News Japan, Fibromyalgia News Jerusalem, Fibromyalgia News Korea, Fibromyalgia News Southeast Asia, Fibromyalgia News Turkey, Fibromyalgia News Wisconsin, Fibromyalgia Press Releases, Fibromyalia News Germany, Finland, FMS, FMS Global News, Genetic, Genetic Disorders, Global News, Health, Italy, Japan, Medical Journals, Medical Research, Medical University, Mexico, Mexico City, Montreal, News, News Australia, News Belgium, News Canada, News Denmark, News France, News India, News Ireland, News Israel, News Italy, News Japan, News Jerusalem, News Korea, News Montreal, News Nigeria, News Norway, News Quebec, News Saskatchewan, News Scotland, News Southeast Asia, News Spain, News Sweden, News Toronto, News Turkey, News UK, News Wisconsin, Non Malignant Chronic Pain, North Carolina, Ontario, Ontario Genometrics, Ottawa, Ottawa City Feed, Ottawa City Feeds, Oxford, Pain, Pain Management, Philadelphia, Research, Seattle, Spain, Surrey and Sussex, Swedish, Switzerland, Syndromes, Tenderpoints, Toronto, Toronto City Feed, Universities, US, USA, Virginia, Washington D.C. City Feed, Washington DC, World News. Bookmark the permalink.

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