The genetics of fibromyalgia syndrome

Dan Buskila‌1, Piercarlo Sarzi-Puttini‌2 & Jacob N Ablin‌3
1Ben Gurion University, Department of Medicine H, Soroka Medical Center and Faculty of Health Sciences, Beer Sheva, Israel. dbuskila@bgumail.bgu.ac.il
2L Sacco University Hospital, Senior Rheumatologist, Rheumatology Unit,Via GB Grassi 74, 20157 Milano, Italy. sarzi@tiscali.it
3Tel-Aviv University, Departments of Rheumatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv, Israel. ajacob@post.tau.ac.il
† Author for correspondence

Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. Although the etiology of FMS is not completely understood, varieties of neuroendocrine disturbances, as well as abnormalities of autonomic function, have been implicated in its pathogenesis. The exposure of a genetically predisposed individual to a host of environmental stressors is presumed to lead to the development of FMS. Fibromyalgia overlaps with several related syndromes, collectively compromising the spectrum of the functional somatic disorder. FMS is characterized by a strong familial aggregation. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the etiopathogenesis of FMS. These polymorphisms are not specific for FMS and are similarly associated with additional comorbid conditions. The mode of inheritance in FMS is unknown, but it is most probably polygenic. Recognition of these gene polymorphisms may help to better subgroup FMS patients and to guide a more rational pharmacological approach. Future genetic studies conducted in larger cohorts of FMS patients and matched control groups may further illuminate the role of genetics in FMS.

Summary
Pharmacogenomics

Vol. 8, No. 1, Pages 67-74
(doi:10.2217/14622416.8.1.67)

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About FMS Global News

Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
This entry was posted in Fibrohugs News, Fibromyalgia, Fibromyalgia Blogs, Fibromyalgia News, FMS, FMS Global News, Genetic Disorders, Global News, Tenderpoints. Bookmark the permalink.

One Response to The genetics of fibromyalgia syndrome

  1. Pingback:   Genetics, Fibroymalgia, and Addictive Behaviors — The Fibro Follies

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