Anti-polymer antibody in Italian fibromyalgic patients.

Bazzichi L, Giacomelli C, De Feo F, Giuliano T, Rossi A, Doveri M, Tani C, Wilson RB, Bombardieri S.

ABSTRACT: The objectives of our study were to evaluate the presence of antipolymer antibody (APA) seropositivity in 285 Italian patients affected by primary fibromyalgia (FM) and to verify if APA levels correlate with the disease severity and cytokine levels. APA levels were determined on serum samples by an indirect ELISA kit that detect IgG APA. Cytokines (IL-1, IL-6, IL-8, IL-10 and TNF-alpha) were measured by ELISA in plasma. The impact of fibromyalgia on the quality of life was estimated using the “Fibromyalgia Impact Questionnaire” (FIQ), while pain severity was evaluated using a Visual Analogic Scale (VAS). Patients were also characterized by the presence of tiredness, stiffness, non restorative sleep, anxiety, depression, tension headache, irritable bowel syndrome, temporomandibular dysfunction, Raynaud phenomena. Using a cut-off value of 30 U, APA positive values were detected in 60 FM patients (21.05%) and in 15 healthy controls (15.00%) without significant differences among their levels or percentage of seropositivity. FM patients with moderate and severe symptoms had slightly higher APA levels with respect to patients with mild symptoms. APA seropositive patients exhibited significant correlations between APA levels and FIQ (P=0.042), tiredness (P=0.003) and IL-1 levels (P=0.0072). In conclusion, APA cannot be considered a marker of disease in Italian FM patients. However, its presence might permit the identification of a subset of FM patients with more severe symptoms and who may respond differently to different therapeutic strategies.

PMID: 17822528 [PubMed – as supplied by publisher]

1: Arthritis Res Ther. 2007 Sep 6;9(5):R86 [Epub ahead of print]

FMS Global News

Fibromyalgia Support

Tenderpoints

Source

Advertisements

About FMS Global News

Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
This entry was posted in Europe, Feeds, Fibrohugs, Fibrohugs News, Fibromyalgia Blogs, Fibromyalgia News, Fibromyalgia News Italy, FM, FMS Global News, Global News, Health, Medical, News, News Italy, NIH, RSS, Science, Tenderpoints. Bookmark the permalink.

Leave a Reply

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s