Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia.

Martinez-Lavin M.

National Institute of Cardiology, Juan Badiano 1, 14080 Mexico City, Mexico. mmlavin@infosel.net.mx.

ABSTRACT: Stress is a state of disharmony, or threatened homeostasis. A stressor could have a psychological origin or a biological origin. Societies have become more intricate with industrialization, and modern individuals try to adapt to the new defiance by forcing their stress response system. The main component of the stress response network is the autonomic nervous system. The present article reviews current knowledge on autonomic dysfunction in fibromyalgia. Sympathetic hyperactivity has been consistently described by diverse groups of investigators. Fibromyalgia is proposed to be a sympathetically maintained neuropathic pain syndrome, and genomic data support this contention. Autonomic dysfunction may also explain other fibromyalgia features not related to pain.

PMID: 17626613 [PubMed – as supplied by publisher]

1: Arthritis Res Ther. 2007 Jul 6;9(4):216 [Epub ahead of print]

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Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
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