Striatal grey matter increase in patients suffering from fibromyalgia – A voxel-based morphometry study.

Schmidt-Wilcke T, Luerding R, Weigand T, Jürgens T, Schuierer G, Leinisch E, Bogdahn U.

Department of Neurology, Universitätsklinik Regensburg, Universitätsstraße 84, D-93053 Regensburg, Germany.

Fibromyalgia (FM), among other chronic pain syndromes, such as chronic tension type headache and atypical face pain, is classified as a so-called dysfunctional pain syndrome. Patients with fibromyalgia suffer from widespread, “deep” muscle pain and often report concomitant depressive episodes, fatigue and cognitive deficits. Clear evidence for structural abnormalities within the muscles or soft tissue of fibromyalgia patients is lacking. There is growing evidence that clinical pain in fibromyalgia has to be understood in terms of pathological activity of central structures involved in nociception. We applied MR-imaging and voxel-based morphometry, to determine whether fibromyalgia is associated with altered local brain morphology. We investigated 20 patients with the diagnosis of primary fibromyalgia and 22 healthy controls. VBM revealed a conspicuous pattern of altered brain morphology in the right superior temporal gyrus (decrease in grey matter), the left posterior thalamus (decrease in grey matter), in the left orbitofrontal cortex (increase in grey matter), left cerebellum (increase in grey matter) and in the striatum bilaterally (increase in grey matter). Our data suggest that fibromyalgia is associated with structural changes in the CNS of patients suffering from this chronic pain disorder. They might reflect either a consequence of chronic nociceptive input or they might be causative to the pathogenesis of fibromyalgia. The affected areas are known to be both, part of the somatosensory system and part of the motor system.

PMID: 17587497 [PubMed – as supplied by publisher]

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Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
This entry was posted in Article, Britain, British, Central Nervous System, Chronic Multisymptom Illness, Chronic Myofacial Pain, Chronic Pain, Chronic Pain Disorders, Chronic Widespread Pain, Clinical Pain, Dysfunctional Pain Processing, Dysfunctional Pain Syndrome, Europe, Fatigue, Feeds, Fibrohugs, Fibrohugs News, Fibromyalgia, Fibromyalgia Blogs, Fibromyalgia News, Fibromyalgia News Belgium, Fibromyalgia News Deutschland, Fibromyalgia News France, Fibromyalgia News Israel, Fibromyalgia News Italy, Fibromyalgia News Japan, Fibromyalgia News Jerusalem, Fibromyalgia News Korea, Fibromyalgia News Southeast Asia, Fibromyalgia News Turkey, Fibromyalgia News Wisconsin, Fibromyalgia Press Releases, Fibromyalia News Germany, FMS, FMS Global News, FSS, Functional Somatic Syndrome, Global News, Health, Health Care, Invisible Illness, Invisible Illnesses, Japan, Medical Journals, Medical Research, Medical University, Mexico, Mexico City, Myofacial Pain Syndrome, News, News Australia, News Belgium, News Canada, News France, News India, News Ireland, News Israel, News Italy, News Japan, News Jerusalem, News Korea, News Montreal, News Nigeria, News Norway, News Quebec, News Saskatchewan, News Scotland, News Southeast Asia, News Spain, News Sweden, News Toronto, News Turkey, News UK, News Wisconsin, Nigeria, North Carolina, Ontario, Ottawa, Oxford, Pain, Pain Management, Pain Matrix, Philadelphia, Physiology, Research, RLS, RSS, Seattle, Sleep Disorders, Sleep Disturbance, Sleep Quality, Southeast Asia, Statistics, Stockholm, Swedish, Switzerland, Syndromes, Temporomandibular Joint Disorders, Tenderpoints, The Netherlands., Therapies, TMJ, Toronto, Universities, US, USA, Virginia, Washington DC, World, World News. Bookmark the permalink.

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