Narrative review: the pathophysiology of fibromyalgia.

1: Ann Intern Med. 2007 May 15;146(10):726-34.

Abeles AM, Pillinger MH, Solitar BM, Abeles M.

New York University School of Medicine, New York University Hospital for Joint Diseases, and New York Harbor Healthcare System, New York, New York 10003, USA.

Primary fibromyalgia is a common yet poorly understood syndrome characterized by diffuse chronic pain accompanied by other somatic symptoms, including poor sleep, fatigue, and stiffness, in the absence of disease. Fibromyalgia does not have a distinct cause or pathology. Nevertheless, in the past decade, the study of chronic pain has yielded new insights into the pathophysiology of fibromyalgia and related chronic pain disorders. Accruing evidence shows that patients with fibromyalgia experience pain differently from the general population because of dysfunctional pain processing in the central nervous system. Aberrant pain processing, which can result in chronic pain and associated symptoms, may be the result of several interplaying mechanisms, including central sensitization, blunting of inhibitory pain pathways, alterations in neurotransmitters, and psychiatric comorbid conditions. This review provides an overview of the mechanisms currently thought to be partly responsible for the chronic diffuse pain typical of fibromyalgia.

PMID: 17502633 [PubMed – in process]

FMS Global News

Tenderpoints

Advertisements

About FMS Global News

Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
This entry was posted in Central Nervous System, Chronic Fatigue, Chronic Fatigue Syndrome, Chronic Insomnia, Chronic Multisymptom Illness, Chronic Pain, Chronic Pain Disorders, Chronic Widespread Pain, Clinical, Clinical Pain, Diseases, Dysfunctional Pain Processing, Europe, Fatigue, Feeds, Fibrohugs, Fibrohugs News, Fibromyalgia, Fibromyalgia Blogs, Fibromyalgia News, Fibromyalgia News Belgium, Fibromyalgia News Deutschland, Fibromyalgia News France, Fibromyalgia News Israel, Fibromyalgia News Italy, Fibromyalgia News Japan, Fibromyalgia News Jerusalem, Fibromyalgia News Korea, Fibromyalgia News Southeast Asia, Fibromyalgia News Turkey, Fibromyalgia Press Releases, Fibromyalia News Germany, FMS Global News, Genetic Disorders, Global News, Health, Health Care, Hypersensitivity, Invisible Illnesses, Medical, Medical Journals, Medical Research, Medical University, Myofacial Pain Syndrome, Narcotics, Neurotransmitters, News, News Australia, News Belgium, News Canada, News France, News India, News Ireland, News Israel, News Italy, News Japan, News Jerusalem, News Korea, News Montreal, News Nigeria, News Norway, News Quebec, News Saskatchewan, News Scotland, News Spain, News Sweden, News Turkey, News UK, Nigeria, North Carolina, Ontario, Ottawa, Pain, Pain Management, Pain Matrix, Philadelphia, Physiology, Poor Sleep, Research, Rheumatism, Rheumatoid Arthritis, RSS, Sleep Disorders, Sleep Disturbance, Sleep Quality, Statistics, Stockholm, Surrey and Sussex, Swedish, Syndromes, Tenderpoints, US, Virginia, Washington DC, World, World News. Bookmark the permalink.

Leave a Reply

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s