Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain?

Kuchinad A, Schweinhardt P, Seminowicz DA, Wood PB, Chizh BA, Bushnell MC.

McGill Centre for Research on Pain, McGill University, Montreal, Quebec, Canada H3A 2B2.

Fibromyalgia is an intractable widespread pain disorder that is most frequently diagnosed in women. It has traditionally been classified as either a musculoskeletal disease or a psychological disorder. Accumulating evidence now suggests that fibromyalgia may be associated with CNS dysfunction. In this study, we investigate anatomical changes in the brain associated with fibromyalgia. Using voxel-based morphometric analysis of magnetic resonance brain images, we examined the brains of 10 female fibromyalgia patients and 10 healthy controls. We found that fibromyalgia patients had significantly less total gray matter volume and showed a 3.3 times greater age-associated decrease in gray matter than healthy controls. The longer the individuals had had fibromyalgia, the greater the gray matter loss, with each year of fibromyalgia being equivalent to 9.5 times the loss in normal aging. In addition, fibromyalgia patients demonstrated significantly less gray matter density than healthy controls in several brain regions, including the cingulate, insular and medial frontal cortices, and parahippocampal gyri. The neuroanatomical changes that we see in fibromyalgia patients contribute additional evidence of CNS involvement in fibromyalgia. In particular, fibromyalgia appears to be associated with an acceleration of age-related changes in the very substance of the brain. Moreover, the regions in which we demonstrate objective changes may be functionally linked to core features of the disorder including affective disturbances and chronic widespread pain.

PMID: 17428976 [PubMed – in process]

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Folllowing Rick Usher's death in December 2008, at his request in September of that year, I had agreed, as his principal contributor and an experienced journalist, to run the FMS Global News service due to his heavy commitments to music and raising research funds through this avenue. Following his sad and sudden death I hope to continue his work as he would have wished.
This entry was posted in Article, Autoimmune Diseases, Awareness, Britain, Chronic Fatigue, Chronic Fatigue Syndrome, Chronic Insomnia, Chronic Multisymptom Illness, Chronic Myofacial Pain, Chronic Pain, Clinical, Clinical Pain, Europe, Feeds, Fibrohugs, Fibrohugs News, Fibromyalgia, Fibromyalgia News, Fibromyalgia News Deutschland, Fibromyalgia News Israel, Fibromyalgia News Jerusalem, Fibromyalgia News Korea, Fibromyalgia News Southeast Asia, Fibromyalia News Germany, FMS Global News, Global News, Health, Hypersensitivity, Invisible Illness, Medical, Medical Journals, Medical Research, Medical University, Multiple Chemical Sensitivity, Myofacial Pain Syndrome, News, News Australia, News Canada, News India, News Ireland, News Israel, News Jerusalem, News Korea, News Montreal, News Norway, News Quebec, News Saskatchewan, News Scotland, News Spain, News Sweden, News UK, North Carolina, Ontario, Ontario Research and Development, Ottawa, Pain, Pain Management, Philadelphia, Physiology, Rheumatism, RSS, Sleep Disorders, Statistics, Stockholm, Swedish, Tenderpoints, Therapies, Toronto, Universities, US, Virginia, World, World News, World Wide, Worldwide. Bookmark the permalink.

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