Category Archives: RLS

EUROPEAN NETWORK of FIBROMYALGIA ASSOCIATIONS

From the News Desk of Jeanne Hambleton

PRESS RELEASE -28.01.2009

 

The European Medicines Agency (EMEA) are to  have a consultation with a delegation from the European Network of Fibromyalgia Associations (ENFA) in an attempt to understand the need for medical treatments for fibromyalgia in Europe.


Brussels –
Following an invitation by the EMEA, the European Network of Fibromyalgia Associations (ENFA) has agreed to attend a consultation meeting with EMEA, where ENFA representatives will share their knowledge and experiences related to the disease of Fibromyalgia that some 14 million Europeans are suffering from.  One of the biggest challenges that the patients have been facing is the lack of officially recognized medical treatment options in the European Union whereas there are three drugs in the United States of America approved by the Food and Drug Administration: Cymbalta from Eli Lilly, Lyrica from Pfizer and recently authorised Savella from Forest & Cypress.

 

The European Declaration 69/2008 on Fibromyalgia that has been recently adopted by the European Parliament, symbolizing the awareness raised around Fibromyalgia, calls for actions on specific issues from European Institutions to improve healthcare surrounding the disease, e.g. investment in research and provision of better diagnosis and treatment.  In addition, the European Health Commissioner Ms. Vassiliou’s remarks (E-6262/08EN) on the treatment of Fibromyalgia demonstrates encouraging willingness of the European Commission to address various concerns laid out in the Declaration on Fibromyalgia.

“We hope that this new drive on Fibromyalgia awareness will bring the end to the impasse of medical treatment for Fibromyalgia patients in the EU”, said Mr. Robert Boelhouwer, President of ENFA. 

Fibromyalgia is a complex disease with a variety of symptoms in addition to the defining symptom – chronic widespread pain. It is estimated that 14 million people in Europe suffer from fibromyalgia and the condition is more prevalent with women (87%).  Fibromyalgia imposes large economic burdens on society as well as on affected individuals. The debilitating symptoms often result in lost work days, lost income and disability payments. Due to lack of awareness, on average patients in Europe see 3-4 physicians and take multiple medications over the course of several years before they receive a diagnosis of Fibromyalgia.

Mr. Boelhouwer said, “Increasing awareness of Fibromyalgia among healthcare professionals and patients will bring enormous benefits to patients, healthcare providers and the society in general by managing the burden of the disease.” he continues, “Having this in mind, ENFA welcomes the proactive role that both the European Parliament and the European Commission have taken up in raising the awareness of Fibromyalgia.”

 

 

Contact:  European Network of Fibromyalgia Associations (ENFA)

Mr. Robert Boelhouwer President of ENFA

contact@enfa-europe.eu  - www.enfa-europe.eu


 About ENFA

ENFA is a network of patient association and support groups working in close consultation with the national association in the relevant country. Our joint missions are to conquer the myths and misunderstandings around Fibromyalgia. The network will help collectively push forward the boundaries which currently exist in understanding, experiencing and treatment of Fibromyalgia. Our main goal is to see fibromyalgia receiving the recognition it deserves across Europe as an illness in its own right.


 

 

CONGO’S BILL AND THE RACE AGAINST TIME

by Jeanne Hambleton  © 2008
NFA Leader Against Pain-Advocate  

A committee of the New Jersey Senate has considered a new bill called Congo’s Law and there are hopes that Congo, the German Shepherd dog, will no longer be under sentence of death.

See original story: Congo gets world wide support

Congo was put on “death row” last June as a vicious dog after protecting his mistress, a female dog and three puppies, from an alleged attack with rake by a gardening contractor. When news of her fate reached the Internet animal activists and dog lovers all over the world signed petitions and sent emails to the Judge in Princeton, home of Congo, to save the dog’s life.

This week thanks to a friend, Anne Soden, who lives in Princeton and took part in one of the demonstrations to save Congo, I can bring you news that an American Assemblyman called Neil M Cohen from the New Jersey Senate has proposed a Bill to save the life of Congo, the German Shepherd dog sentenced to death. Thanks Anne.

Neil Cohen is quoted as saying,”Congo’s case underscores the need for the state to modernize the law that deals with dog attacks so it is fair for the owners and the animals.”

Congo’s Bill would revise state animal control law provisions that are alleged to be archaic and barbaric, by making it more difficult to label a dog vicious or to put an animal down.

But a USA website (http://abbyK9.blogspot.com) which shows a picture of two of the James children with Congo, adds a cautious note to say, “Please note that Congo being returned to his family is only temporary while the case goes through the appeal. Congo could still be put to sleep for protecting her family. So please, keep contacting the governor’s office to have this matter put to rest once and for all. The calls and emails are helping!” Details of who and where to write or email appear later in this story.

NEW JERSEY SENATE

In December Congo’s Bill, that would immediately change the state’s vicious dog laws, made its first passage through the Senate.

The New Jersey Assemblyman Neil Cohen, who took this action, is an avid defender of the rights of animals and has sponsored several measures to ensure the humane treatment of animals. He has met Congo and his owners, the James family, at their home in Princeton to raise awareness of his legislation and the dog’s potential fate. Neil Cohen says that under current law the only defense for a dog declared vicious is if the dog has been provoked and acted in defense to protect itself, its offspring, its owner or a family member of the owner.

“The nature of a dog is to protect those around them,” said the Assemblyman. “It’s outrageous that Congo may have been provoked into attacking and this fact is being ignored by authorities.”

A lawyer for Congo’s owners has argued that Congo was provoked when the dog mauled a landscaper on June 5 outside a home in Princeton Township. Neil Cohen’s bill (A-4597) will clarify and revise the current vicious dog law to make it more equitable.

The bill would take into consideration provocation by treating a dog provoked to attack differently than an unprovoked dog that caused bodily injury to a person or domestic animal during an attack.

The Assemblyman said the bill would define striking, grabbing, poking and prodding as threatening actions and behaviors that could incite a dog to defend itself, its offspring or its owner or the owner’s family. The legislation would raise the bar for declaring a dog as vicious. It would require a dog to be found vicious beyond a reasonable doubt — the same standard used for humans charged with a crime. The measure also would give municipal courts an alternative to humanely destroying a vicious dog by giving the owner the option to comply with precautions for keeping a potentially dangerous dog.

During the disposition and appeals process, the bill would allow an owner to keep their dog as long as they complied with current law’s precautions for keeping a potentially dangerous dog. Precautions for owners keeping a dog deemed potentially dangerous include posting signs on their property and minimizing a dog’s potential threat to people and other animals. The bill also would allow an owner and owner’s family to visit their dog during times when their dog might be impounded. The bill would establish a three-month statute of limitations for animal control officer to seize and impound alleged vicious or potentially dangerous dogs.

Neil Cohen said the vicious dog law has not been amended since 1994 and it is long overdue for an update. He hoped his legislation would be fast tracked into law to save the life of Congo.

Congo was ruled vicious by Princeton Township Municipal Judge Russell Annich, Jr., who also ordered that the dog be put down. The judge’s decision has since been stayed and a state Superior Court Judge has allowed the dog to return to his home, pending appeal, with numerous restrictions, including that he is muzzled and kept in a fenced area.

The fate of Congo created a public debate that has lead to more telephone calls, emails, letters and faxes to Governor Jon S. Corzine’s office than any other issue since the governor took office.

The Bill was carried by a vote of 5 to 0. It now heads to the Assembly Speaker who may or may not decide to post it for a vote by the full Assembly.

ON LINE SUPPORT

Broadcaster Warren Eckstein from Santa Monica, California, an internationally known pet and animal expert, has been carrying news of Congo’s Bill on his website.

On December 19 Warren wrote that the New Jersey Assembly Agriculture and Natural Resources Committee today released legislation Assembly Deputy Speaker Neil M. Cohen crafted that would immediately change the state’s vicious dog laws.

It was also reported – you will be pleased to hear – from Warren’s website that Congo and his partner Lucia are so happy to be back together.

Elizabeth James on Warren’s website wrote, “I think the appeal could take months but we are optimistic. God willing, New Jersey Assemblyman Neil Cohen’s proposal of Congo’s Law will go through and that will be the first line of defense. We are still receiving mail and email from well wishers and supporters all around the globe! Thank you for all the support and we will keep you posted as we progress.”

On another local website for Asbury Park Press, APP.com for Jersey for comments, blogs and shares, Tom Baldwin of Gannett State Bureau reported Assemblyman Neil Cohen, a professed dog-lover, is quoted as saying under this bill Congo gets saved and the bill gives municipal judges needed latitude to deal with dog-bite cases.

Tom Baldwin continues and I smiled, “The story connects hot-issue circuitry. Mix the gentility of leafy, enlightened Princeton with the dog-lovers and the immigration debate — the landscaper is reported to have been an illegal from Honduras — and the story quickly won global appeal.
“Locally, not since a whale swam up the Delaware River to freshwater Trenton in April 2005 has an animal story grabbed headlines, aside from some reported coyote attacks and New Jersey’s enduring debate over whether to allow hunters shoot black bears.”
And finally Abby K 9 tells us the way to get Congo’s ruling reversed, hopefully, is to contact New Jersey governor Jim Corzine. His office is taking calls (and counting them) to support overturning the death sentence for Congo the German Shepherd.

The governor’s office can be contacted at Office of the Governor, PO Box 001,Trenton, NJ 08625. Calling is preferred, (609-292-6000) but you can also email them through the website.

http://www.nj.gov/cgi-bin/governor/govmail/govmail_1.pl

Choose “Law & Public Safety” on the drop-down menu and on the next page, choose “Pardons & Clemency”. It only takes a few seconds to call – they are interested in the number of callers, not what you have to say – and it does not take much longer to email. Assemblyman Cohen telephone number is (908) 624-0880.

CONGO’S BILL
The following includes a statement from the Bill outlining the relevant details of Congo’s Bill.

On December 17 Senate Bill No. 3019 (A.4597) was introduced for the 212th Legislature. The synopsis said it revises vicious and potentially dangerous dog law; designated Congo’s Law.

The final Statement in the Act concerning vicious and potentially dangerous dogs and designated as Congo’s Law, and amending and supplementing P.L.1989, c.307.
enacted by the Senate and General Assembly of the State of New Jersey said,

“This bill clarifies and revises several provisions of the State law that address vicious and potentially dangerous dogs.  It is designated as Congo’s Law in recognition of Congo, a dog in Princeton, New Jersey, that was declared a vicious dog and subject to an order to be euthanized when, by many accounts, it was protecting its owner and the owner’s family members when a landscaping crew, against the owner’s instructions, came onto the owner’s property.

“Specifically, the bill defines the terms ‘provoked’ and ‘unprovoked.’  Whether a dog is provoked or not is currently the only defense under the law to prevent a dog from being declared vicious when it is acting in defense of itself, its offspring, its owner, or a family member of its owner.  Also, under current law, if a municipal court declares a dog to be vicious, it must be humanely destroyed.  This bill provides the municipal court an alternative to humanely destroying a dog that is declared vicious.

“Under the bill, the court may, for equitable reasons, choose an alternative to destroying the dog if the alternative is sufficient to protect the public and is at least as protective and restrictive as the precautions required for keeping a potentially dangerous dog.  The bill allows for an owner to keep the dog pending disposition of the case and any appeals if the owner agrees to comply with those precautions.  The precautions include posting certain signs on the property and minimizing the dog’s contact and threat to people and other animals in specific ways. 

“In addition, the bill authorizes the court to modify certain requirements for potentially dangerous dogs, and vicious dogs that remain with their owners, to be reasonable, affordable and appropriate to the owner’s circumstances. The bill further provides for visitation by the owner and the owner’s family during any impoundment that is required.

“Furthermore, the bill raises the burden of proof in most cases for finding a dog to be vicious or potentially dangerous to beyond a reasonable doubt, instead of by clear and convincing evidence.  The municipal burden of proof for demonstrating that a dog was not provoked or that the injury was not accidental would be by clear and convincing evidence.  The bill clarifies under the law’s hearing provisions to provide that a hearing on whether the dog is vicious or potentially dangerous will be held unless the owner agrees to relinquish ownership of the dog. 

“The bill further requires the notice to the owner to inform the owner of the potential consequences of not replying to the notice within seven days.  Under current law and the bill, if the owner does not reply within seven days of the notice, or if the owner relinquishes ownership of the dog, the dog may be humanely destroyed.  The bill eliminates the requirement to tattoo a potentially dangerous dog.

“The bill also modifies the provision under current law concerning liability insurance for potentially dangerous dogs.  The bill allows the court to order this insurance for potentially dangerous dogs, and if applicable, vicious dogs, if it is available.  Furthermore, the court is directed to determine a sufficient and reasonable amount of coverage and a reasonable cost for that coverage; and the insurance company is directed to notify the municipality of the coverage and any lapsing of the policy, if the company can lawfully do so.

“Finally, the bill provides additional protections for the public by authorizing municipalities, if a municipality chooses to do so, to establish procedures for recording and investigating complaints about, and requiring appropriate notice to the public concerning, dogs within the jurisdiction of the municipality that are reported to exhibit menacing, threatening, or other aggressive behavior that may lead to injury to a person or a domestic animal, or that have injured a person but have not been the subject of an action pursuant to the State vicious and potentially dangerous dog law.  The municipality must establish these procedures and requirements by ordinance and it is authorized to require an owner of a dog subject to complaints to post signs or take other action determined necessary by the municipality for the protection of the public.

“With Assembly Floor Amendments
(Proposed By Assemblyman Cohen) ADOPTED: DECEMBER 13, 2007
 
These amendments:
      (1) make changes to the definition of “provoked” in the bill;
      (2) remove certain time limitations by which certain actions may be taken in section 2 of the bill; and
      (3) change the municipal burden of proof with respect to whether the dog was not provoked or that the injury was not accidental from beyond a reasonable doubt to by clear and convincing evidence.

Clause 15 states – This act shall take effect immediately, and shall apply to all pending cases and cases in the process of being adjudicated as of the date of enactment of this act, and to any dogs under court order for humane destruction as of January 1, 2007 but which have not been destroyed as of the date of enactment of this act.

The Bill must now go before the Full Assembly.

See Also: http://fmsglobalnews.wordpress.com/2007/12/02/congo-on-doggie-death-row-gets-worldwide-support-and-tv-publicity-for-his-reprieve/

A committee of the New Jersey Senate has considered a new bill called Congo’s Law and there are hopes that Congo, the German Shepherd dog, will no longer be under sentence of death.

Congo was put on “death row” last June as a vicious dog after protecting his mistress, a female dog and three puppies, from an alleged attack with rake by a gardening contractor. When news of his fate reached the Internet animal activists and dog lovers all over the world signed petitions and sent emails to the Judge in Princeton, home of Congo, to save the dog’s life.

This week thanks to a friend, Anne Soden, who lives in Princeton and took part in one of the demonstration to save Congo, I can bring you news that an American Assemblyman called Neil M Cohen from the New Jersey Senate has proposed a Bill to save the life of Congo, the German Shepherd dog sentenced to death. Thanks Anne.

Neil Cohen is quoted as saying,”Congo’s case underscores the need for the state to modernize the law that deals with dog attacks so it is fair for the owners and the animals.”

Congo’s Bill would revise state animal control law provisions that are alleged to be archaic and barbaric, by making it more difficult to label a dog vicious or to put an animal down.

But a USA website (http://abbyK9.blogspot.com) which shows a picture of two of the James children with Congo, adds a cautious note to say, “Please note that Congo being returned to his family is only temporary while the case goes through the appeal. Congo could still be put to sleep for protecting his family. So please, keep contacting the governor’s office to have this matter put to rest once and for all. The calls and emails are helping!” Details of who and where to write or email appear later in this story.

NEW JERSEY SENATE

In December Congo’s Bill, that would immediately change the state’s vicious dog laws, made its first passage through the Senate.

The New Jersey Assemblyman Neil Cohen, who took this action, is an avid defender of the rights of animal and has sponsored several measures to ensure the humane treatment of animals. He has met Congo and his owners, the James family, at their home in Princeton to raise awareness of his legislation and the dog’s potential fate. Neil Cohen says that under current law the only defense for a dog declared vicious is if the dog has been provoked and acted in defense to protect itself, its offspring, its owner or a family member of the owner.

“The nature of a dog is to protect those around them,” said the Assemblyman. “It’s outrageous that Congo may have been provoked into attacking and this fact is being ignored by authorities.”

A lawyer for Congo’s owners has argued that Congo was provoked when the dog mauled a landscaper on June 5 outside a home in Princeton Township. Neil Cohen’s bill (A-4597) will clarify and revise the current vicious dog law to make it more equitable.

The bill would take into consideration provocation by treating a dog provoked to attack differently than an unprovoked dog that caused bodily injury to a person or domestic animal during an attack.

The Assemblyman said the bill would define striking, grabbing, poking and prodding as threatening actions and behaviors that could incite a dog to defend itself, its offspring or its owner or the owner’s family. The legislation would raise the bar for declaring a dog as vicious. It would require a dog to be found vicious beyond a reasonable doubt — the same standard used for humans charged with a crime. The measure also would give municipal courts an alternative to humanely destroying a vicious dog by giving the owner the option to comply with precautions for keeping a potentially dangerous dog.

During the disposition and appeals process, the bill would allow an owner to keep their dog as long as they complied with current law’s precautions for keeping a potentially dangerous dog. Precautions for owners keeping a dog deemed potentially dangerous include posting signs on their property and minimizing a dog’s potential threat to people and other animals. The bill also would allow an owner and owner’s family to visit their dog during times when their dog might be impounded. The bill would establish a three-month statute of limitations for animal control officer to seize and impound alleged vicious or potentially dangerous dogs.

Neil Cohen said the vicious dog law has not been amended since 1994 and it is long overdue for an update. He hoped his legislation would be fast tracked into law to save the life of the Congo.

Congo was ruled vicious by Princeton Township Municipal Judge Russell Annich, Jr., who also ordered that the dog be put down. The judge’s decision has since been stayed and a state Superior Court Judge has allowed the dog to return to his home, pending appeal, with numerous restrictions, including that he is muzzled and kept in a fenced area.

The fate of Congo created a public debate that has lead to more telephone calls, emails, letters and faxes to Governor Jon S. Corzine’s office than any other issue since the governor took office.

The Bill was carried by a vote of 5 to 0. It now heads to the Assembly Speaker who may or may not decide to post it for a vote by the full Assembly.

ON LINE SUPPORT

Broadcaster Warren Eckstein from Santa Monica, California, an internationally known pet and animal expert, has been carrying news of Congo’s Bill on his website.

On December 19 Warren wrote that the New Jersey Assembly Agriculture and Natural Resources Committee today released legislation Assembly Deputy Speaker Neil M. Cohen crafted that would immediately change the state’s vicious dog laws.

It was also reported – you will be pleased to hear – from Warren’s website that Congo and his partner Lucia are so happy to be back together.

Elizabeth James on Warren’s website wrote, “I think the appeal could take months but we are optimistic. God willing, New Jersey Assemblyman Neil Cohen’s proposal of Congo’s Law will go through and that will be the first line of defense. We are still receiving mail and email from well wishers and supporters all around the globe! Thank you for all the support and we will keep you posted as we progress.”

On another local website for Asbury Park Press, APP.com for Jersey for comments, blogs and shares, Tom Baldwin of Gannett State Bureau reported Assemblyman Neil Cohen, a professed dog-lover, is quoted as saying under this bill Congo gets saved and the bill gives municipal judges needed latitude to deal with dog-bite cases.

Tom Baldwin continues and I smiled, “The story connects hot-issue circuitry. Mix the gentility of leafy, enlightened Princeton with the dog-lovers and the immigration debate — the landscaper is reported to have been an illegal from Honduras — and the story quickly won global appeal.
“Locally, not since a whale swam up the Delaware River to freshwater Trenton in April 2005 has an animal story grabbed headlines, aside from some reported coyote attacks and New Jersey’s enduring debate over whether to allow hunters shoot black bears.”
And finally Abby K 9 tells us the way to get Congo’s ruling reversed, hopefully, is to contact New Jersey governor Jim Corzine. His office is taking calls (and counting them) to support overturning the death sentence for Congo the German Shepherd.

The governor’s office can be contacted at Office of the Governor, PO Box 001,Trenton, NJ 08625. Calling is preferred, (609-292-6000) but you can also email them through the website.

http://www.nj.gov/cgi-bin/governor/govmail/govmail_1.pl

Choose “Law & Public Safety” on the drop-down menu and on the next page, choose “Pardons & Clemency”. It only takes a few seconds to call – they are interested in the number of callers, not what you have to say – and it does not take much longer to email. Assemblyman Cohen telephone number is (908) 624-0880.

CONGO’S BILL
The following includes a statement from the Bill outlining the relevant details of Congo’s Bill.

On December 17 Senate Bill No. 3019 (A.4597) was introduced for the 212th Legislature. The synopsis said it revises vicious and potentially dangerous dog law; designated Congo’s Law.

The final Statement in the Act concerning vicious and potentially dangerous dogs and designated as Congo’s Law, and amending and supplementing P.L.1989, c.307.
enacted by the Senate and General Assembly of the State of New Jersey said,

“This bill clarifies and revises several provisions of the State law that address vicious and potentially dangerous dogs.  It is designated as Congo’s Law in recognition of Congo, a dog in Princeton, New Jersey, that was declared a vicious dog and subject to an order to be euthanized when, by many accounts, it was protecting its owner and the owner’s family members when a landscaping crew, against the owner’s instructions, came onto the owner’s property.

“Specifically, the bill defines the terms ‘provoked’ and ‘unprovoked.’  Whether a dog is provoked or not is currently the only defense under the law to prevent a dog from being declared vicious when it is acting in defense of itself, its offspring, its owner, or a family member of its owner.  Also, under current law, if a municipal court declares a dog to be vicious, it must be humanely destroyed.  This bill provides the municipal court an alternative to humanely destroying a dog that is declared vicious.

“Under the bill, the court may, for equitable reasons, choose an alternative to destroying the dog if the alternative is sufficient to protect the public and is at least as protective and restrictive as the precautions required for keeping a potentially dangerous dog.  The bill allows for an owner to keep the dog pending disposition of the case and any appeals if the owner agrees to comply with those precautions.  The precautions include posting certain signs on the property and minimizing the dog’s contact and threat to people and other animals in specific ways. 

“In addition, the bill authorizes the court to modify certain requirements for potentially dangerous dogs, and vicious dogs that remain with their owners, to be reasonable, affordable and appropriate to the owner’s circumstances. The bill further provides for visitation by the owner and the owner’s family during any impoundment that is required.

“Furthermore, the bill raises the burden of proof in most cases for finding a dog to be vicious or potentially dangerous to beyond a reasonable doubt, instead of by clear and convincing evidence.  The municipal burden of proof for demonstrating that a dog was not provoked or that the injury was not accidental would be by clear and convincing evidence.  The bill clarifies under the law’s hearing provisions to provide that a hearing on whether the dog is vicious or potentially dangerous will be held unless the owner agrees to relinquish ownership of the dog. 

“The bill further requires the notice to the owner to inform the owner of the potential consequences of not replying to the notice within seven days.  Under current law and the bill, if the owner does not reply within seven days of the notice, or if the owner relinquishes ownership of the dog, the dog may be humanely destroyed.  The bill eliminates the requirement to tattoo a potentially dangerous dog.

“The bill also modifies the provision under current law concerning liability insurance for potentially dangerous dogs.  The bill allows the court to order this insurance for potentially dangerous dogs, and if applicable, vicious dogs, if it is available.  Furthermore, the court is directed to determine a sufficient and reasonable amount of coverage and a reasonable cost for that coverage; and the insurance company is directed to notify the municipality of the coverage and any lapsing of the policy, if the company can lawfully do so.

“Finally, the bill provides additional protections for the public by authorizing municipalities, if a municipality chooses to do so, to establish procedures for recording and investigating complaints about, and requiring appropriate notice to the public concerning, dogs within the jurisdiction of the municipality that are reported to exhibit menacing, threatening, or other aggressive behavior that may lead to injury to a person or a domestic animal, or that have injured a person but have not been the subject of an action pursuant to the State vicious and potentially dangerous dog law.  The municipality must establish these procedures and requirements by ordinance and it is authorized to require an owner of a dog subject to complaints to post signs or take other action determined necessary by the municipality for the protection of the public.

“With Assembly Floor Amendments
(Proposed By Assemblyman Cohen) ADOPTED: DECEMBER 13, 2007
 
These amendments:
      (1) make changes to the definition of “provoked” in the bill;
      (2) remove certain time limitations by which certain actions may be taken in section 2 of the bill; and
      (3) change the municipal burden of proof with respect to whether the dog was not provoked or that the injury was not accidental from beyond a reasonable doubt to by clear and convincing evidence.

Clause 15 states – This act shall take effect immediately, and shall apply to all pending cases and cases in the process of being adjudicated as of the date of enactment of this act, and to any dogs under court order for humane destruction as of January 1, 2007 but which have not been destroyed as of the date of enactment of this act.

The Bill must now go before the Full Assembly.

by Jeanne Hambleton  © 2008
NFA Leader Against Pain-Advocate  

A committee of the New Jersey Senate has considered a new bill called Congo’s Law and there are hopes that Congo, the German Shepherd dog, will no longer be under sentence of death.

Congo was put on “death row” last June as a vicious dog after protecting his mistress, a female dog and three puppies, from an alleged attack with rake by a gardening contractor. When news of his fate reached the Internet animal activists and dog lovers all over the world signed petitions and sent emails to the Judge in Princeton, home of Congo, to save the dog’s life.

This week thanks to a friend, Anne Soden, who lives in Princeton and took part in one of the demonstration to save Congo, I can bring you news that an American Assemblyman called Neil M Cohen from the New Jersey Senate has proposed a Bill to save the life of Congo, the German Shepherd dog sentenced to death. Thanks Anne.

Neil Cohen is quoted as saying,”Congo’s case underscores the need for the state to modernize the law that deals with dog attacks so it is fair for the owners and the animals.”

Congo’s Bill would revise state animal control law provisions that are alleged to be archaic and barbaric, by making it more difficult to label a dog vicious or to put an animal down.

But a USA website (http://abbyK9.blogspot.com) which shows a picture of two of the James children with Congo, adds a cautious note to say, “Please note that Congo being returned to his family is only temporary while the case goes through the appeal. Congo could still be put to sleep for protecting his family. So please, keep contacting the governor’s office to have this matter put to rest once and for all. The calls and emails are helping!” Details of who and where to write or email appear later in this story.

NEW JERSEY SENATE

In December Congo’s Bill, that would immediately change the state’s vicious dog laws, made its first passage through the Senate.

The New Jersey Assemblyman Neil Cohen, who took this action, is an avid defender of the rights of animal and has sponsored several measures to ensure the humane treatment of animals. He has met Congo and his owners, the James family, at their home in Princeton to raise awareness of his legislation and the dog’s potential fate. Neil Cohen says that under current law the only defense for a dog declared vicious is if the dog has been provoked and acted in defense to protect itself, its offspring, its owner or a family member of the owner.

“The nature of a dog is to protect those around them,” said the Assemblyman. “It’s outrageous that Congo may have been provoked into attacking and this fact is being ignored by authorities.”

A lawyer for Congo’s owners has argued that Congo was provoked when the dog mauled a landscaper on June 5 outside a home in Princeton Township. Neil Cohen’s bill (A-4597) will clarify and revise the current vicious dog law to make it more equitable.

The bill would take into consideration provocation by treating a dog provoked to attack differently than an unprovoked dog that caused bodily injury to a person or domestic animal during an attack.

The Assemblyman said the bill would define striking, grabbing, poking and prodding as threatening actions and behaviors that could incite a dog to defend itself, its offspring or its owner or the owner’s family. The legislation would raise the bar for declaring a dog as vicious. It would require a dog to be found vicious beyond a reasonable doubt — the same standard used for humans charged with a crime. The measure also would give municipal courts an alternative to humanely destroying a vicious dog by giving the owner the option to comply with precautions for keeping a potentially dangerous dog.

During the disposition and appeals process, the bill would allow an owner to keep their dog as long as they complied with current law’s precautions for keeping a potentially dangerous dog. Precautions for owners keeping a dog deemed potentially dangerous include posting signs on their property and minimizing a dog’s potential threat to people and other animals. The bill also would allow an owner and owner’s family to visit their dog during times when their dog might be impounded. The bill would establish a three-month statute of limitations for animal control officer to
seize and impound alleged vicious or potentially dangerous dogs.

Neil Cohen said the vicious dog law has not been amended since 1994 and it is long overdue for an update. He hoped his legislation would be fast tracked into law to save the life of the Congo.

Congo was ruled vicious by Princeton Township Municipal Judge Russell Annich, Jr., who also ordered that the dog be put down. The judge’s decision has since been stayed and a state Superior Court Judge has allowed the dog to return to his home, pending appeal, with numerous restrictions, including that he is muzzled and kept in a fenced area.

The fate of Congo created a public debate that has lead to more telephone calls, emails, letters and faxes to Governor Jon S. Corzine’s office than any other issue since the governor took office.

The Bill was carried by a vote of 5 to 0. It now heads to the Assembly Speaker who may or may not decide to post it for a vote by the full Assembly.

ON LINE SUPPORT

Broadcaster Warren Eckstein from Santa Monica, California, an internationally known pet and animal expert, has been carrying news of Congo’s Bill on his website.

(http://wareneckstein.com)

On December 19 Warren wrote that the New Jersey Assembly Agriculture and Natural Resources Committee today released legislation Assembly Deputy Speaker Neil M. Cohen crafted that would immediately change the state’s vicious dog laws.

It was also reported – you will be pleased to hear – from Warren’s website that Congo and his partner Lucia are so happy to be back together.

Elizabeth James on Warren’s website wrote, “I think the appeal could take months but we are optimistic. God willing, New Jersey Assemblyman Neil Cohen’s proposal of Congo’s Law will go through and that will be the first line of defense. We are still receiving mail and email from well wishers and supporters all around the globe! Thank you for all the support and we will keep you posted as we progress.”

On another local website for Asbury Park Press, APP.com for Jersey for comments, blogs and shares, Tom Baldwin of Gannett State Bureau reported Assemblyman Neil Cohen, a professed dog-lover, is quoted as saying under this bill Congo gets saved and the bill gives municipal judges needed latitude to deal with dog-bite cases.

Tom Baldwin continues and I smiled, “The story connects hot-issue circuitry. Mix the gentility of leafy, enlightened Princeton with the dog-lovers and the immigration debate — the landscaper is reported to have been an illegal from Honduras — and the story quickly won global appeal.
“Locally, not since a whale swam up the Delaware River to freshwater Trenton in April 2005 has an animal story grabbed headlines, aside from some reported coyote attacks and New Jersey’s enduring debate over whether to allow hunters shoot black bears.”
And finally Abby K 9 tells us the way to get Congo’s ruling reversed, hopefully, is to contact New Jersey governor Jim Corzine. His office is taking calls (and counting them) to support overturning the death sentence for Congo the German Shepherd.

The governor’s office can be contacted at Office of the Governor, PO Box 001,Trenton, NJ 08625. Calling is preferred, (609-292-6000) but you can also email them through the website.

http://www.nj.gov/cgi-bin/governor/govmail/govmail_1.pl

Choose “Law & Public Safety” on the drop-down menu and on the next page, choose “Pardons & Clemency”. It only takes a few seconds to call – they are interested in the number of callers, not what you have to say – and it does not take much longer to email. Assemblyman Cohen telephone number is (908) 624-0880.

CONGO’S BILL
The following includes a statement from the Bill outlining the relevant details of Congo’s Bill.

On December 17 Senate Bill No. 3019 (A.4597) was introduced for the 212th Legislature. The synopsis said it revises vicious and potentially dangerous dog law; designated Congo’s Law.

The final Statement in the Act concerning vicious and potentially dangerous dogs and designated as Congo’s Law, and amending and supplementing P.L.1989, c.307.
enacted by the Senate and General Assembly of the State of New Jersey said,

“This bill clarifies and revises several provisions of the State law that address vicious and potentially dangerous dogs.  It is designated as Congo’s Law in recognition of Congo, a dog in Princeton, New Jersey, that was declared a vicious dog and subject to an order to be euthanized when, by many accounts, it was protecting its owner and the owner’s family members when a landscaping crew, against the owner’s instructions, came onto the owner’s property.

“Specifically, the bill defines the terms ‘provoked’ and ‘unprovoked.’  Whether a dog is provoked or not is currently the only defense under the law to prevent a dog from being declared vicious when it is acting in defense of itself, its offspring, its owner, or a family member of its owner.  Also, under current law, if a municipal court declares a dog to be vicious, it must be humanely destroyed.  This bill provides the municipal court an alternative to humanely destroying a dog that is declared vicious.

“Under the bill, the court may, for equitable reasons, choose an alternative to destroying the dog if the alternative is sufficient to protect the public and is at least as protective and restrictive as the precautions required for keeping a potentially dangerous dog.  The bill allows for an owner to keep the dog pending disposition of the case and any appeals if the owner agrees to comply with those precautions.  The precautions include posting certain signs on the property and minimizing the dog’s contact and threat to people and other animals in specific ways. 

“In addition, the bill authorizes the court to modify certain requirements for potentially dangerous dogs, and vicious dogs that remain with their owners, to be reasonable, affordable and appropriate to the owner’s circumstances. The bill further provides for visitation by the owner and the owner’s family during any impoundment that is required.

“Furthermore, the bill raises the burden of proof in most cases for finding a dog to be vicious or potentially dangerous to beyond a reasonable doubt, instead of by clear and convincing evidence.  The municipal burden of proof for demonstrating that a dog was not provoked or that the injury was not accidental would be by clear and convincing evidence.  The bill clarifies under the law’s hearing provisions to provide that a hearing on whether the dog is vicious or potentially dangerous will be held unless the owner agrees to relinquish ownership of the dog. 

“The bill further requires the notice to the owner to inform the owner of the potential consequences of not replying to the notice within seven days.  Under current law and the bill, if the owner does not reply within seven days of the notice, or if the owner relinquishes ownership of the dog, the dog may be humanely destroyed.  The bill eliminates the requirement to tattoo a potentially dangerous dog.

“The bill also modifies the provision under current law concerning liability insurance for potentially dangerous dogs.  The bill allows the court to order this insurance for potentially dangerous dogs, and if applicable, vicious dogs, if it is available.  Furthermore, the court is directed to determine a sufficient and reasonable amount of coverage and a reasonable cost for that coverage; and the insurance company is directed to notify the municipality of the coverage and any lapsing of the policy, if the company can lawfully do so.

“Finally, the bill provides additional protections for the public by authorizing municipalities, if a municipality chooses to do so, to establish procedures for recording and investigating complaints about, and requiring appropriate notice to the public concerning, dogs within the jurisdiction of the municipality that are reported to exhibit menacing, threatening, or other aggressive behavior that may lead to injury to a person or a domestic animal, or that have injured a person but have not been the subject of an action pursuant to the State vicious and potentially dangerous dog law.  The municipality must establish these procedures and requirements by ordinance and it is authorized to require an owner of a dog subject to complaints to post signs or take other action determined necessary by the municipality for the protection of the public.

“With Assembly Floor Amendments
(Proposed By Assemblyman Cohen) ADOPTED: DECEMBER 13, 2007
 
These amendments:
      (1) make changes to the definition of “provoked” in the bill;
      (2) remove certain time limitations by which certain actions may be taken in section 2 of the bill; and
      (3) change the municipal burden of proof with respect to whether the dog was not provoked or that the injury was not accidental from beyond a reasonable doubt to by clear and convincing evidence.

Clause 15 states – This act shall take effect immediately, and shall apply to all pending cases and cases in the process of being adjudicated as of the date of enactment of this act, and to any dogs under court order for humane destruction as of January 1, 2007 but which have not been destroyed as of the date of enactment of this act.

The Bill must now go before the Full Assembly.

See Also: http://www.ipetitions.com/petition/savecongo/

Restless legs syndrome doubles risk of stroke and heart disease

Contact: Angela Babb
ababb@aan.com
651-695-2789
American Academy of Neurology

ST. PAUL, Minn. – People with restless legs syndrome (RLS) are twice as likely to have a stroke or heart disease compared to people without RLS, and the risk is greatest in those with the most frequent and severe symptoms, according to research published in the January 1, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology.

The study, the largest of its kind enrolling both men and women, involved 3,433 people with an average age of 68 who were enrolled in the Sleep Heart Health Study. Participants were diagnosed with RLS by detailed questionnaire and asked if they had been diagnosed with a variety of systemic diseases including cardiovascular disease and cerebrovascular disease. Of the participants, nearly seven percent of women and three percent of men had RLS.

The study found people with RLS were more than twice as likely to have cardiovascular disease or cerebrovascular disease. The results remained the same after adjusting for age, sex, race, body mass index, diabetes, high blood pressure, high blood pressure medication, HDL/LDL cholesterol levels, and smoking.

“The association of RLS with heart disease and stroke was strongest in those people who had RLS symptoms at least 16 times per month,” said study author John W. Winkelman, MD, PhD, with Harvard Medical School in Boston. “There was also an increased risk among people who said their RLS symptoms were severe compared to those with less bothersome symptoms.”

Winkelman says although this study does not show that RLS causes cardiovascular and cerebrovascular disease, a number of potential mechanics for such a process exist. “In particular, most people with RLS have as many as 200 to 300 periodic leg movements per night of sleep and these leg movements are associated with substantial acute increases in both blood pressure and heart rate, which may, over the long term, produce cardiovascular or cerebrovascular disease.

Winkelman says there are limitations to the study, including that the diagnosis of RLS was self-reported by questionnaire rather than by clinical interview.

###
The study was supported by grants from the National Heart, Lung and Blood Institute.

The American Academy of Neurology, an association of more than 20,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as stroke, Alzheimer’s disease, epilepsy, Parkinson disease, and multiple sclerosis.

For more information about the American Academy of Neurology, visit http://www.aan.com.

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Opioids for managing chronic non-malignant pain: safe and effective prescribing.

Kahan M, Srivastava A, Wilson L, Mailis-Gagnon A, Midmer D.
Addiction Medical Service, St Joseph’s Health Centre, Toronto, Ontario, Canada. kahanm@stjoe.on.ca

OBJECTIVE: To review the evidence on safe and effective prescribing of opioids for chronic non-malignant pain.

QUALITY OF EVIDENCE: MEDLINE was searched using the terms “opioid effectiveness” and “adverse effects.” There is strong evidence that opioids are effective for both nociceptive and neuropathic pain, but limited evidence that they are effective for pain disorder. There is little information on their effectiveness at high doses or on the adverse effects of high doses.

MAIN MESSAGE: Opioids should be initiated after an adequate trial of acetaminophen or nonsteroidal anti-inflammatory drugs for nociceptive pain and of tricyclic antidepressants or anticonvulsants for neuropathic pain. Patients should be asked to sign treatment agreements and to give informed consent to treatment. Patients should experience a graded analgesic response with each dose increase. Titrate doses of immediate-release opioids slowly upward until pain reduction is achieved, and then switch patients to controlled-release opioids. Most patients with chronic non-malignant pain can be managed with<300 mg/d of morphine (or equivalent).

CONCLUSION: Opioids are safe and effective for managing chronic pain.

PMID: 17279219 [PubMed - indexed for MEDLINE]

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The classification of fibromyalgia syndrome.

Müller W, Schneider EM, Stratz T.
Rheumatologische Forschungsabteilung, Weihermatten 1, 79713, Bad Säckingen, Germany.

As has been shown by a number of working groups, primary fibromyalgia syndrome does not represent a single clinical entity. It is possible to distinguish between a subgroup with high pain sensitivity and no associated psychiatric condition, a second and a third subgroup characterized by depression associated with fibromyalgia syndrome, and a fourth group with somatoform pain disorder of the fibromyalgia type. Mild inflammatory processes must be considered as the cause in the first group, while depression is combined with fibromyalgia in the second and the third group. In the fourth group, serious previous or still existing psychological problems or also insufficient coping with illness symptoms must be regarded as the reason for pain chronification. Group 1 benefits from a blocking of the 5-HT3 receptors by means of tropisetron, for example. This does not only affect pain chronification but also the inflammatory process itself. Group 2 and 3 needs antidepressant treatment, whereas the focus should be on psychotherapy in group 4. Groups 1, 2 and 3 will also profit from multimodal physical treatment programs, to a certain extent this applies to group 4 as well. So-called mixed types require a combination of therapeutic measures.

PMID: 17653720 [PubMed - as supplied by publisher]

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Publication trends in chronic fatigue syndrome: Comparisons with fibromyalgia and fatigue: 1995-2004.

Friedberg F, Sohl S, Schmeizer B.
Department of Psychiatry and Behavioral Medicine, Stony Brook University, NY, USA.

OBJECTIVE: In order to identify publishing patterns in chronic fatigue syndrome (CFS), we compared the annual number of peer review articles for CFS, fibromyalgia (FM), and non-CFS fatigue over a recent decade (1995-2004).

METHOD: Citations were drawn from Ovid/Medline, PsychInfo, and the Journal of Chronic Fatigue Syndrome for peer review articles focusing on CFS, FM, and fatigue for each year of the decade ending in 2004. Statistics included chi-square, tests for differences in proportions, and regression-based curve estimation.

RESULTS: The frequency of CFS peer review articles did not significantly change from the first half to the second half of the decade (1995-2004). By comparison, the output of both FM and fatigue articles significantly increased (P<.0001). A quadratic model (inverted U shape; P<.02) best fit the data for CFS annual publication frequency. By comparison, exponential models best fit the data for both FM (P<.0001) and fatigue (P<.0001) citations. The highest percentage of citations (15-16%) for both CFS and FM fell within the domains of diagnosis, physiopathology, and psychology. For fatigue, almost one third (31.4%) of the citations were focused on etiology, while psychology (11.5%) and physiopathology (10.4%) articles were the next most cited. Based on first-author affiliation, CFS articles were most likely to originate in the United States (37.7%), England (31.4%), and the Netherlands (4.9%).

CONCLUSION: The output of CFS peer review articles has not increased over the past decade, while the number of FM and fatigue articles has increased substantially.

PMID: 17662750 [PubMed - in process]

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Characteristics and healthcare costs of patients with fibromyalgia syndrome.

Berger A, Dukes E, Martin S, Edelsberg J, Oster G.
Policy Analysis, Inc. (PAI), Brookline, MA, USA.

Purpose: To examine the characteristics and healthcare costs of fibromyalgia syndrome (FMS) patients in clinical practice. Materials and methods: Using a US health-insurance database, we identified all patients, aged >/= 18 years, with any healthcare encounters for FMS (ICD-9-CM diagnosis code 729.1) in each year of the 3-year period, 1 July 2002 to 30 June 2005. A comparison group was then constituted, consisting of randomly selected patients without any healthcare encounters for FMS during this 3-year period. Comparison group patients were matched to FMS patients based on age and sex. Characteristics and healthcare costs of FMS patients and comparison group patients were then examined over the 1-year period, 1 July 2004 to 30 June 2005 (the most recent year for which data were available at the time of the study). Results: The study sample consisted of 33,176 FMS patients and an identical number in the comparison group. Mean age was 46 years, and 75% were women. FMS patients were more likely to have various comorbidities, including painful neuropathies (23% vs. 3% for comparison group), anxiety (5% vs. 1%), and depression (12% vs. 3%) (all p < 0.001); they also were more likely to have used pain-related pharmacotherapy (65% vs. 34% for comparison group; p < 0.001). Mean (SD) total healthcare costs over 12 months were about three times higher among FMS patients [$9573 ($20,135) vs. $3291 ($13,643); p < 0.001]; median costs were fivefold higher ($4247 vs. $822; p < 0.001). Conclusions: Patients with FMS have comparatively high levels of comorbidities and high levels of healthcare utilization and cost.

PMID: 17655684 [PubMed - as supplied by publisher]

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Mouse genome will help identify causes of environmental disease

Research on the DNA of 15 mouse strains commonly used in biomedical studies is expected to help scientists determine the genes related to susceptibility to environmental disease. The body of data is now publicly available in a catalog of genetic variants, which displays the data as a mouse haplotype map, a tool that separates chromosomes in to many small segments, helping researchers find genes and genetic variations in mice that may affect health and disease. The haplotype map appearing online in the July 29th issue of Nature is the first published full descriptive analysis of the “Mouse Genome Resequencing and SNP Discovery Project” conducted by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health.

“These data allow researchers to compare the genetic makeup of one mouse strain to another, and perform the necessary genetic analyses to determine why some individuals might be more susceptible to disease than another. This puts us one step closer to understanding individual susceptibility to environmental toxins in humans. We also hope that pharmaceutical companies developing new treatments for environmental diseases will find these data and this paper as a valuable resource,” said David A. Schwartz. M.D., NIEHS Director.

The paper describes in detail the laborious and technology-driven approaches that were used to identify 8.27 million high quality SNPs distributed among the genomes of 15 mouse strains. Single Nucleotide Polymorphisms, or SNPs (known as snips), are single genetic changes, or variations, that can occur in a DNA sequence.

Much of the project was conducted through a contract between the National Toxicology Program at NIEHS and Perlegen Sciences, Inc. of Mountain View Calif.

“The database of mouse genetic variation should facilitate a wide range of important biological studies, and helps demonstrate the utility of this array technology approach,” said David R. Cox, M.D., Ph.D., chief scientific officer at Perlegen Sciences, Inc.

The Perlegen scientists used C57BL/6J the first mouse strain to undergo DNA sequencing as their standard reference to conduct the re-sequencing on the four wild-derived and eleven classical mouse strains. The technology used, the oligonucleotide array, was also used to discover common DNA variation in the human genome.

The arrays looked at about 1.49 billion bases (58 percent) of the 2.57 billion base pair of their standard reference strain. The data were then used to develop the haplotype map which contains 40,898 segments.

“The data will be a valuable resource to many, including the National Toxicology Program,” Schwartz says. The National Toxicology Program (NTP) is an interagency program, headquartered at NIEHS, with the mission to coordinate, conduct and communicate toxicological research across the U.S. government.

“The NTP is looking forward to exploring the responses of these strains of mice to various environmental agents,” said John Bucher, Ph.D., the new associate director of the NTP.

Frank M. Johnson, Ph. D., an NTP research geneticist and one of the authors of the Nature paper, adds that systematically characterizing even more mouse strains for susceptibility to toxins will not only help with genetic analysis, but better position researchers to do intervention studies.

###
The data are publicly available on the National Center for Biotechnology Information Web site at http://www.ncbi.nlm.nih.gov/SNP/ and at a Web site developed by Perlegen at http://mouse.perlegen.com which allows researchers to download SNPs, genotypes, and LR-PCR primer pairs, which are currently mapped to NCBI Build 36.

In addition to the NTP and Perlegen Sciences scientists, other key collaborators on the project include researchers from the Department of Computer Science and Department of Human Genetics, University of California, Los Angeles; the Department of Computer Science and Engineering, University of California, San Diego; The Jackson Laboratory, Bar Harbor, Maine; Broad Institute of Harvard and MIT; and the Center for Human Genetic Research, Massachusetts General Hospital.

Reference: Kelly A. Frazer, Eleazar Eskin, Hyun Min Kang, Molly A. Bogue, David A. Hinds, Erica J. Beilharz, Robert V. Gupta, Julie Montgomery, Matt M. Morenzoni, Geoffrey B. Nilsen, Charit L. Pethiyagoda, Laura L. Stuve, Frank M. Johnson, Mark J. Daly, Claire M. Wade, David R. Cox. A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature, 2007

The National Institute of Environmental Health Sciences (NIEHS), a component of the National Institutes of Health, supports research to understand the effects of the environment on human health. For more information on environmental health topics, please visit our website at http://www.niehs.nih.gov/.

The National Institutes of Health (NIH) — The Nation’s Medical Research Agency — includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

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Researchers discover gene responsible for Restless Legs Syndrome

An international team of researchers has identified the first gene associated with Restless Legs Syndrome (RLS), a common sleep disorder affecting tens of millions of people worldwide. The findings will be published July 18 in the online edition of the New England Journal of Medicine and will appear in an upcoming printed edition of the journal. The work was led by scientists at Emory University and deCODE Genetics, Inc., in Reykjavik, Iceland.

Restless legs syndrome is a condition that produces an intense, often irresistible urge to move the legs and is a major cause of insomnia and sleep disruption. RLS affects approximately 10 percent of the U.S. population and about one percent of school-aged children. The discovery provides strong new evidence that RLS is a genuine syndrome, a fact which has recently been the subject of some debate.

“We now have concrete evidence that RLS is an authentic disorder with recognizable features and underlying biological basis,” says David Rye, MD, PhD, professor of neurology at Emory University School of Medicine, director of the Emory Healthcare Program in Sleep, and one of the study’s lead authors. “This is the most definitive link between genetics and RLS that has been reported to date. We have known for quite some time that the majority of RLS patients have a close family member with the disorder, and now we have found a gene which is clearly linked to RLS,” says Dr. Rye.

The researchers report a population-attributable risk for RLS of at least 50 percent, meaning that were the gene variant not present, more than half of all RLS cases would disappear.

The variant is very common–nearly 65 percent of the population carries at least one copy of the variant. Two copies of the variant more than doubles one’s risk of experiencing RLS.

According to Dr. Rye, having two copies does not ensure that one will develop symptoms of RLS. “There remain yet-to-be-identified medical, environmental or genetic factors that appear necessary to translate genetic susceptibility into RLS symptoms,” he says.

RLS researchers have known for some time that anemia and low iron levels contribute to more severe RLS symptoms. The current study revealed the gene variant to be more common in Icelandic subjects deficient in iron.

The medical breakthrough is the result of a four-year study led jointly by Dr. Rye and deCODE Genetics scientist Dr. Hreinn Stefansson. With the goal of identifying genes causing RLS, the research team conducted genome-wide scans of nearly 1,000 Icelanders and 188 Americans. A new chip technology was applied along with genome wide association methods.

This approach allowed Drs. Rye and Stefansson to probe more than 300,000 small regions (single nucleotides) distributed across the entire genome for differences more common to RLS sufferers as compared to population-based controls.

According to Dr. Rye, very little is known about the function of the gene variant discovered.

“Additional work will be required to translate this knowledge into a plausible mechanism and, in turn, more rational and better treatments,” notes Dr. Rye. “Future advances will depend upon additional monies which to this point have come solely from private foundations and industry.”

Dr. Rye says RLS is exceedingly common but not taught as a part of standard medical education, in part leading many medical professionals, educators and academicians to challenge its commonality and authenticity.

###
Donald L. Bliwise, PhD, professor of neurology at Emory University, and Salina Waddy MD, an assistant professor of neurology, also contributed to the study.

For more information on the Emory Sleep Center or to schedule an appointment, please call 404-712-SLEEP.

Contact: Jennifer Johnson
jennifer.johnson@emory.edu
404-727-5696
Emory University

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Fibromyalgia patients show an abnormal dopamine response to pain.

Wood PB, Schweinhardt P, Jaeger E, Dagher A, Hakyemez H, Rabiner EA, Bushnell MC, Chizh BA.

McGill University Centre for Research on Pain, Faculty of Dentistry, 3640 University Street, Strathcona Building, Montreal, QC, Canada, H3A 2B2.

Fibromyalgia is characterized by chronic widespread pain and bodily tenderness and is often accompanied by affective disturbances. Accumulating evidence indicates that fibromyalgia may involve a dysfunction of modulatory systems in the brain. While brain dopamine is best known for its role in pleasure, motivation and motor control, recent evidence suggests that it is also involved in pain modulation. Because dopamine is implicated in both pain modulation and affective processing, we hypothesized that fibromyalgia may involve a disturbance of dopaminergic neurotransmission. Fibromyalgia patients and matched healthy control subjects were subjected to deep muscle pain produced by injection of hypertonic saline into the anterior tibialis muscle. In order to determine the endogenous release of dopamine in response to painful stimulation, we used positron emission tomography to examine binding of [(11)C]-raclopride (D2/D3 ligand) in the brain during injection of painful hypertonic saline and nonpainful normal saline. Fibromyalgia patients experienced the hypertonic saline as more painful than healthy control subjects. Control subjects released dopamine in the basal ganglia during the painful stimulation, whereas fibromyalgia patients did not. In control subjects, the amount of dopamine release correlated with the amount of perceived pain but in fibromyalgia patients no such correlation was observed. These findings provide the first direct evidence that fibromyalgia patients have an abnormal dopamine response to pain. The disrupted dopaminergic reactivity in fibromyalgia patients could be a critical factor underlying the widespread pain and discomfort in fibromyalgia and suggests that the therapeutic effects of dopaminergic treatments for this intractable disorder should be explored.

PMID: 17610577 [PubMed - in process]

1: Eur J Neurosci. 2007 Jun;25(12):3576-82.

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