Thermal and Visceral Hypersensitivity in Irritable Bowel Syndrome Patients With and Without Fibromyalgia.

Moshiree B, Price DD, Robinson ME, Gaible R, Nicholas Verne G.

1: Clin J Pain. 2007 May;23(4):323-330.

Departments of *Medicine daggerOral and Maxillofacial Surgery double daggerNeuroscience section signClinical and Health Psychology, University of Florida Colleges of Medicine, Dentistry, Public Health and Health Professions, Gainesville, FL parallelNorth Florida/South Georgia Veteran Health System.

BACKGROUND: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by both visceral and somatic hyperalgesia, producing a similar effect seen with the central hypersensitivity mechanism in fibromyalgia (FM).

OBJECTIVES: The aim of the current study was to compare magnitudes of visceral and thermal hypersensitivity in IBS patients and FM patients with IBS (FM+IBS) compared with healthy controls.

METHODS: Female patients with IBS (n=12), FM+IBS (n=12), and control participants (n=13) rated pain intensity to hot water immersion (45 and 47 degrees C) of the hand/foot and to phasic distension of the rectum (35, 55 mm Hg) on a Mechanical Visual Analog Scale. The data were analyzed with 3 separate 1-way analyses of variance with post hoc Tukey tests.

RESULTS: For both thermal and visceral stimuli, the control group had lower pain ratings than either the IBS or FM+IBS groups.

PMID: 17449993 [PubMed - as supplied by publisher]

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